Halbzeit: 2-0
Bruno Fernandes 60Edinson Cavani 74 90+2
18/04 - 18:45
18/04 - 21:00
| h2h | 2022-05-22 | Leicester City |  | 4-1 |  | Southampton | SP38 | |||
| h2h | 2021-09-18 | Manchester City |  | 0-0 | | Southampton | SP5 | |||
| h2h | 2021-03-10 | Manchester City | | 5-2 | | Southampton | SP33 | |||
| h2h | 2021-02-11 | Wolverhampton |  | 0-2 | | Southampton | 5R | |||
| h2h | 2020-11-29 | Southampton | | 2-3 |  | Manchester United | SP10 | |||
| h2h | 2020-09-12 | Crystal Palace |  | 1-0 | | Southampton | SP1 | |||
| h2h | 2019-12-26 | Chelsea |  | 0-2 | | Southampton | SP19 | |||
| h2h | 2019-04-13 | Southampton | | 3-1 | | Wolverhampton | SP34 | |||
| h2h | 2019-01-02 | Chelsea | | 0-0 | | Southampton | SP21 | |||
| h2h | 2018-12-08 | Cardiff City |  | 1-0 | | Southampton | SP16 |
| h2h | 2022-04-09 | Everton |  | 1-0 | | Manchester United | SP32 | |||
| h2h | 2022-03-12 | Manchester United | | 3-2 |  | Tottenham | SP29 | |||
| h2h | 2022-01-22 | Manchester United | | 1-0 |  | West Ham | SP23 | |||
| h2h | 2021-12-30 | Manchester United | | 3-1 |  | Burnley | SP20 | |||
| h2h | 2021-11-20 | Watford |  | 4-1 | | Manchester United | SP12 | |||
| h2h | 2021-09-22 | Manchester United | | 0-1 | | West Ham | 3R | |||
| h2h | 2021-04-18 | Manchester United | | 3-1 | | Burnley | SP32 | |||
| h2h | 2021-02-06 | Manchester United | | 3-3 | | Everton | SP23 | |||
| h2h | 2020-12-29 | Manchester United | | 1-0 | | Wolverhampton | SP16 | |||
| h2h | 2020-11-29 | Southampton | | 2-3 | | Manchester United | SP10 |
