25/04 - 21:00
| 2021/12/05 | Portland Timbers |  | 2-0 |  | Real Salt Lake |
| 2021/12/05 | Philadelphia Union |  | 1-2 |  | New York City FC |
| 2021/11/25 | Colorado Rapids |  | 0-1 | | Portland Timbers | ||||
| 2021/11/28 | Sporting KC |  | 1-2 | | Real Salt Lake |
| SP | T | GT | Pts | |||
|---|---|---|---|---|---|---|
| 1 |  | NE Revolution | 34 | 65 | 41 | 73 |
| 2 | | Philadelphia Union | 34 | 48 | 35 | 54 |
| 3 |  | Nashville SC | 34 | 55 | 33 | 54 |
| 4 | | New York City FC | 34 | 56 | 36 | 51 |
| 5 |  | Atlanta United | 34 | 45 | 37 | 51 |
| 6 |  | Orlando City | 34 | 50 | 48 | 51 |
| 7 |  | NY Red Bulls | 34 | 39 | 33 | 48 |
| 8 |  | DC United | 34 | 56 | 54 | 47 |
| 9 |  | Columbus Crew | 34 | 46 | 45 | 47 |
| 10 |  | CF Montréal | 34 | 46 | 44 | 46 |
| 11 |  | Inter Miami CF | 34 | 36 | 53 | 41 |
| 12 |  | Chicago Fire | 34 | 36 | 54 | 34 |
| 13 |  | Toronto FC | 34 | 39 | 66 | 28 |
| 14 |  | FC Cincinnati | 34 | 37 | 74 | 20 |
| SP | T | GT | Pts | |||
|---|---|---|---|---|---|---|
| 1 | | Colorado Rapids | 34 | 51 | 35 | 61 |
| 2 |  | Seattle Sounders | 34 | 53 | 33 | 60 |
| 3 | | Sporting KC | 34 | 58 | 40 | 58 |
| 4 | | Portland Timbers | 34 | 56 | 52 | 55 |
| 5 |  | Minnesota United | 34 | 42 | 44 | 49 |
| 6 |  | Vancouver Whitecaps | 34 | 45 | 45 | 49 |
| 7 | | Real Salt Lake | 34 | 55 | 54 | 48 |
| 8 |  | LA Galaxy | 34 | 50 | 54 | 48 |
| 9 |  | Los Angeles FC | 34 | 53 | 51 | 45 |
| 10 |  | SJ Earthquakes | 34 | 46 | 54 | 41 |
| 11 |  | FC Dallas | 34 | 47 | 56 | 33 |
| 12 |  | Austin FC | 34 | 35 | 56 | 31 |
| 13 |  | Houston Dynamo | 34 | 36 | 54 | 30 |
 | |
|
| 2 |
|
Hany Mukhtar Nashville SC | 19 G |
| 2 |
|
Ola Kamara DC United | 19 G |
| 4 |
|
Adam Buksa NE Revolution | 17 G |
| 4 |
|
Raúl Ruidíaz Seattle Sounders | 17 G |
| 1 |
|
Djordje Mihailovic CF Montréal | 14 AST |
| 3 |
|
Maxi Morález New York City FC | 13 AST |
| 4 |
|
Jack Price Colorado Rapids | 12 AST |
| 5 |
|
Hany Mukhtar Nashville SC | 10 AST |
