| Datum | Anstoßzeit | Heimspiele | Auswärtsspiele | Fase | TV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| h2h | 2021-08-23 | 00:00 | Motagua |  | 3-2 |  | CD Olimpia | 1F | ||||
| h2h | 2021-08-31 | 03:00 | Motagua | | 0-0 |  | Lobos UPNFM | 1F | ||||
| h2h | 2021-09-12 | 01:00 | Lobos UPNFM | | 0-0 | | CD Olimpia | 1F | ||||
| h2h | 2021-09-20 | 00:00 | Lobos UPNFM | | 2-2 | | Motagua | 1F | ||||
| h2h | 2021-10-31 | 23:00 | CD Olimpia | | 2-1 | | Lobos UPNFM | 1F | ||||
| h2h | 2021-11-07 | 02:00 | CD Olimpia | | 0-0 | | Motagua | 1F | ||||
| h2h | 2021-11-19 | 02:05 | Lobos UPNFM | | 1-2 | | Motagua | POff | ||||
| h2h | 2021-11-21 | 02:10 | Motagua | | 3-1 | | Lobos UPNFM | POff | ||||
