02/05 - 20:30
| Orlando City |  | (2-0) |  | Nashville SC | |||||||
| 1 | 31/10 | 00:00 | Orlando City | 1-0 | Nashville SC | Bilanz | |||||
| 2 | 08/11 | 03:00 | Nashville SC | 0-1 | Orlando City | Bilanz | |||||
| Los Angeles FC |  | (2-0) |  | Vancouver Whitecaps | |||||||
| 1 | 29/10 | 03:00 | Los Angeles FC | 5-2 | Vancouver Whitecaps | Bilanz | |||||
| 2 | 06/11 | 01:30 | Vancouver Whitecaps | 0-1 | Los Angeles FC | Bilanz | |||||
| Philadelphia Union |  | (2-0) |  | NE Revolution | |||||||
| 1 | 28/10 | 23:00 | Philadelphia Union | 3-1 | NE Revolution | Bilanz | |||||
| 2 | 09/11 | 01:00 | NE Revolution | 0-1 | Philadelphia Union | Bilanz | |||||
| Houston Dynamo |  | (2-1) |  | Real Salt Lake | |||||||
| 1 | 29/10 | 23:00 | Houston Dynamo | 2-1 | Real Salt Lake | Bilanz | |||||
| 2 | 07/11 | 03:00 | Real Salt Lake | 1-1 (5-4 Elf.) | Houston Dynamo | Bilanz | |||||
| 3 | 12/11 | 00:00 | Houston Dynamo | 1-1 (4-3 Elf.) | Real Salt Lake | Bilanz | |||||
| FC Cincinnati |  | (2-0) |  | NY Red Bulls | |||||||
| 1 | 30/10 | 01:00 | FC Cincinnati | 3-0 | NY Red Bulls | Bilanz | |||||
| 2 | 05/11 | 00:00 | NY Red Bulls | 1-1 (7-8 Elf.) | FC Cincinnati | Bilanz | |||||
| St. Louis City SC |  | (0-2) |  | Sporting KC | |||||||
| 1 | 30/10 | 03:10 | St. Louis City SC | 1-4 | Sporting KC | Bilanz | |||||
| 2 | 05/11 | 23:00 | Sporting KC | 2-1 | St. Louis City SC | Bilanz | |||||
| Columbus Crew |  | (2-1) |  | Atlanta United | |||||||
| 1 | 02/11 | 00:30 | Columbus Crew | 2-0 | Atlanta United | Bilanz | |||||
| 2 | 08/11 | 01:00 | Atlanta United | 4-2 | Columbus Crew | Bilanz | |||||
| 3 | 13/11 | 01:00 | Columbus Crew | 4-2 | Atlanta United | Bilanz | |||||
| Seattle Sounders |  | (2-1) |  | FC Dallas | |||||||
| 1 | 31/10 | 02:00 | Seattle Sounders | 2-0 | FC Dallas | Bilanz | |||||
| 2 | 05/11 | 02:00 | FC Dallas | 3-1 | Seattle Sounders | Bilanz | |||||
| 3 | 11/11 | 04:00 | Seattle Sounders | 1-0 | FC Dallas | Bilanz |
| 2 |
|
Cucho Hernández Columbus Crew | 21 G |
| 3 |
|
Giorgos Giakoumakis Atlanta United | 19 G |
| 3 |
|
Luciano Acosta FC Cincinnati | 19 G |
| 5 |
|
Brian White Vancouver Whitecaps | 16 G |
| 2 |
|
Ryan Gauld Vancouver Whitecaps | 14 AST |
| 3 |
|
Héctor Herrera Houston Dynamo | 13 AST |
| 4 |
|
Luciano Acosta FC Cincinnati | 12 AST |
| 4 |
|
Brooks Lennon Atlanta United | 12 AST |
