| Datum | Anstoßzeit | Heimspiele | Auswärtsspiele | Fase | TV | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | 2021-08-09 | 01:15 | Sol de América |  | 1-0 |  | River Plate | SP4 | ||||
N | 2021-08-30 | 01:00 | River Plate | | 1-5 |  | Guaraní | SP7 | ||||
N | 2021-09-18 | 02:15 | River Plate | | 0-1 |  | Libertad | SP9 | ||||
N | 2021-09-27 | 00:00 | River Plate | | 1-2 |  | Olimpia | SP10 | ||||
N | 2021-10-19 | 01:30 | Cerro Porteño |  | 2-0 | | River Plate | SP12 | ||||
N | 2021-10-23 | 23:00 | River Plate | | 0-2 | | Sol de América | SP13 | ||||
N | 2021-11-05 | 23:00 | River Plate | | 0-2 |  | 12 de Octubre FC | SP15 | ||||
N | 2021-11-20 | 23:45 | Guaraní | | 2-1 | | River Plate | SP16 | ||||
N | 2021-12-03 | 23:30 | Libertad | | 5-0 | | River Plate | SP18 | ||||
